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Target
DNA topoisomerase 1
Ligand
BDBM50081428
Substrate
n/a
Meas. Tech.
ChEBML_208411
IC50
102000±n/a nM
Citation
 Sato, S; Suga, Y; Yoshimura, T; Nakagawa, R; Tsuji, T; Umemura, K; Andoh, T Syntheses of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II. Bioorg Med Chem Lett 9:2653-6 (1999) [PubMed]  Article 
Target
Name:
DNA topoisomerase 1
Synonyms:
DNA topoisomerase I | TOP1_MOUSE | Top-1 | Top1
Type:
PROTEIN
Mol. Mass.:
90922.04
Organism:
Mus musculus
Description:
ChEMBL_208411
Residue:
767
Sequence:
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKERRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRLRDEDDADYKPKKIKTEDIKKEKKRKSEEEEDGKLKKPKNKDKDKKVAEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
  
Inhibitor
Name:
BDBM50081428
Synonyms:
(4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-xanthene-4a-carboxylic acid (2-hydroxy-ethyl)-amide | CHEMBL89464
Type:
Small organic molecule
Emp. Form.:
C17H17NO6
Mol. Mass.:
331.32
SMILES:
Cc1cc(O)c2C(=O)C3=CC=C[C@@H](O)[C@]3(Oc2c1)C(=O)NCCO |c:10,t:8|
Structure:
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