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Target
Vacuolar proton pump subunit B
Ligand
BDBM50086849
Substrate
n/a
Meas. Tech.
ChEBML_148285
IC50
4900±n/a nM
Citation
 Edvinsson, KM; Herslöf, M; Holm, P; Kann, N; Keeling, DJ; Mattsson, JP; Nordén, B; Shcherbukhin, V Solid phase synthesis of diamides as potential bone resorption inhibitors. Bioorg Med Chem Lett 10:503-7 (2000) [PubMed]  Article 
Target
Name:
Vacuolar proton pump subunit B
Synonyms:
Adenosinetriphosphatase | Uncharacterized protein | Vacuolar H-ATPase B subunit osteoclast isozyme
Type:
PROTEIN
Mol. Mass.:
55043.78
Organism:
Gallus gallus
Description:
ChEMBL_148284
Residue:
496
Sequence:
RRMVNGAGPGGAREQAAALTRDFLSQPRLTYKTVSGVNGPLVILDQVKFPRYAEIVHLTLPDGTRRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPAVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVMDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFIAQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQTTLAEFYPRDSTAKH
  
Inhibitor
Name:
BDBM50086849
Synonyms:
3-[(3,4-Dichloro-phenylcarbamoyl)-methyl]-N-(2,2,6,6-tetramethyl-piperidin-4-yl)-benzamide | CHEMBL147307
Type:
Small organic molecule
Emp. Form.:
C24H29Cl2N3O2
Mol. Mass.:
462.412
SMILES:
CC1(C)CC(CC(C)(C)N1)NC(=O)c1cccc(CC(=O)Nc2ccc(Cl)c(Cl)c2)c1
Structure:
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