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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50103880
Substrate
n/a
Meas. Tech.
ChEBML_205216
IC50
490±n/a nM
Citation
 Fan, G; Mar, W; Park, MK; Choi, EW; Kim, K; Kim, S A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives. Bioorg Med Chem Lett 11:2361-3 (2001) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50103880
Synonyms:
Benzoic acid 8-allyl-2-oxo-2H-chromen-7-yl ester | CHEMBL76959
Type:
Small organic molecule
Emp. Form.:
C19H14O4
Mol. Mass.:
306.3121
SMILES:
C=CCc1c(OC(=O)c2ccccc2)ccc2ccc(=O)oc12
Structure:
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