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Target
4-hydroxyphenylpyruvate dioxygenase
Ligand
BDBM50075318
Substrate
n/a
Meas. Tech.
ChEMBL_542 (CHEMBL615562)
IC50
45±n/a nM
Citation
 Huang, M; Yang, DY; Shang, Z; Zou, J; Yu, Q 3D-QSAR studies on 4-hydroxyphenylpyruvate dioxygenase inhibitors by comparative molecular field analysis (CoMFA). Bioorg Med Chem Lett 12:2271-5 (2002) [PubMed]  Article 
Target
Name:
4-hydroxyphenylpyruvate dioxygenase
Synonyms:
HPD | HPPD_PIG
Type:
PROTEIN
Mol. Mass.:
45064.25
Organism:
Sus scrofa
Description:
ChEMBL_541
Residue:
393
Sequence:
MTSYSDKGEKPERGRFLHFHSVTFWVGNAKQAASYYCSKIGFEPLAYKGLETGSREVVSHVVKQDKIVFVFSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAIIVREEVCCAADVRGHHTPLDRARQVWEGTLVEKMTFCLDSRPQPSQTLLHRLLLSKLPKCGLEIIDHIVGNQPDQEMESASQWYMRNLQFHRFWSVDDTQIHTEYSALRSVVMANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRSLRERGVEFLAVPFTYYKQLQEKLKSAKIRVKESIDVLEELKILVDYDEKGYLLQIFTKPMQDRPTVFLEVIQRNNHQGFGAGNFNSLFKAFEEEQELRGNLTDTDPNGVPFRL
  
Inhibitor
Name:
BDBM50075318
Synonyms:
2-(2-Chloro-4-methanesulfonyl-benzoyl)-3-hydroxy-cyclohex-2-enone | CHEMBL73467
Type:
Small organic molecule
Emp. Form.:
C14H13ClO5S
Mol. Mass.:
328.768
SMILES:
CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(Cl)c1
Structure:
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