Reaction Details Report a problem with these data
Target
Lecithin retinol acyltransferase
Ligand
BDBM50124304
Substrate
n/a
Meas. Tech.
ChEMBL_96915 (CHEMBL707894)
IC50
152000±n/a nM
Citation
 Ryu, DH; Tan, CH; Rando, RR Synthesis of (+),(-)-neamine and their positional isomers as potential antibiotics. Bioorg Med Chem Lett 13:901-3 (2003) [PubMed]  Article 
Target
Name:
Lecithin retinol acyltransferase
Synonyms:
LRAT | LRAT_HUMAN | Lecithin retinol acyltransferase | Phosphatidylcholine--retinol O-acyltransferase | Phosphatidylcholine-retinol O-acyltransferase
Type:
PROTEIN
Mol. Mass.:
25705.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_96915
Residue:
230
Sequence:
MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCTGLVSYTTLPAIFIPFFLWMAG
  
Inhibitor
Name:
BDBM50124304
Synonyms:
5-Amino-2-aminomethyl-6-(3,5-diamino-2,6-dihydroxy-cyclohexyloxy)-tetrahydro-pyran-3,4-diol | CHEMBL367060
Type:
Small organic molecule
Emp. Form.:
C12H26N4O6
Mol. Mass.:
322.358
SMILES:
NCC1OC(OC2C(O)C(N)CC(N)C2O)C(N)C(O)C1O
Structure:
Search PDB for entries with ligand similarity: