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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50143423
Substrate
n/a
Meas. Tech.
ChEBML_154471
IC50
210000±n/a nM
Citation
 Shrestha, S; Shim, YS; Kim, KC; Lee, KH; Cho, H Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett 14:1923-6 (2004) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50143423
Synonyms:
CHEMBL176350 | Sodium; 2-hydroxy-5-(4-nitro-phenylazo)-benzoate
Type:
Small organic molecule
Emp. Form.:
C13H8N3O5
Mol. Mass.:
286.2203
SMILES:
Oc1ccc(cc1C([O-])=O)N=Nc1ccc(cc1)[N+]([O-])=O |w:10.10|
Structure:
Search PDB for entries with ligand similarity: