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Target
Acyl-protein thioesterase 1
Ligand
BDBM50011912
Substrate
n/a
Meas. Tech.
ChEBML_100183
IC50
93000±n/a nM
Citation
 Mingeot-Leclercq, MP; Van Schepdael, A; Brasseur, R; Busson, R; Vanderhaeghe, HJ; Claes, PJ; Tulkens, PM New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 2. In vitro and computer-aided toxicological evaluation with respect to interactions with phosphatidylinositol. J Med Chem 34:1476-82 (1991) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1
Type:
PROTEIN
Mol. Mass.:
24708.49
Organism:
Rattus norvegicus
Description:
ChEMBL_12731
Residue:
230
Sequence:
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMPVTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
  
Inhibitor
Name:
BDBM50011912
Synonyms:
4-amino-2-[4,6-diamino-3-(3-amino-6-aminomethyl-4,5-dihydroxytetrahydro-2H-2-pyranyloxy)-2-hydroxycyclohexyloxy]-6-methyltetrahydro-2H-3,5-pyrandiol | 5-amino-2-aminomethyl-6-[4,6-diamino-3-(4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-2-pyranyloxy)-2-hydroxycyclohexyloxy]tetrahydro-2H-3,4-pyrandiol | CHEMBL35509
Type:
Small organic molecule
Emp. Form.:
C18H37N5O9
Mol. Mass.:
467.5145
SMILES:
CC1OC(OC2C(N)CC(N)C(OC3OC(CN)C(O)C(O)C3N)C2O)C(O)C(N)C1O
Structure:
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