Target
Thyroid hormone receptor beta
Ligand
BDBM50225220
Substrate
n/a
Meas. Tech.
ChEMBL_143914 (CHEMBL872845)
IC50
35±n/a nM
Citation
 Yokoyama, NWalker, GNMain, AJStanton, JLMorrissey, MMBoehm, CEngle, ANeubert, ADWasvary, JMStephan, ZF Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. J Med Chem 38:695-707 (1995) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
Erba2 | Nr1a2 | THB_RAT | Thrb | Thyroid Hormone Receptor (TR-beta) | Thyroid hormone receptor beta | Thyroid hormone receptor beta-1 | thyroid beta
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52661.52
Organism:
RAT
Description:
thyroid beta 0 RAT::P18113
Residue:
461
Sequence:
MTPNSMTENRLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM50225220
Synonyms:
CHEMBL559 | D-thyroxine | O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine | dextrothyroxine
Type:
Small organic molecule
Emp. Form.:
C15H11I4NO4
Mol. Mass.:
776.87
SMILES:
N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: