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Target
Aldo-keto reductase family 1 member A1
Ligand
BDBM50054324
Substrate
n/a
Meas. Tech.
ChEMBL_31325 (CHEMBL644878)
IC50
107000±n/a nM
Citation
 Costantino, L; Rastelli, G; Vescovini, K; Cignarella, G; Vianello, P; Del Corso, A; Cappiello, M; Mura, U; Barlocco, D Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors. J Med Chem 39:4396-405 (1996) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member A1
Synonyms:
AK1A1_RAT | Akr1a1 | Aldehyde reductase | Alr
Type:
PROTEIN
Mol. Mass.:
36509.97
Organism:
Rattus norvegicus
Description:
ChEMBL_31321
Residue:
325
Sequence:
MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALSVGYRHIDCASVYGNETEIGEALKESVGAGKAVPREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSITPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY
  
Inhibitor
Name:
BDBM50054324
Synonyms:
(3-Oxo-3,5-dihydro-indeno[1,2-c]pyridazin-2-yl)-acetic acid | CHEMBL433688
Type:
Small organic molecule
Emp. Form.:
C13H10N2O3
Mol. Mass.:
242.2301
SMILES:
OC(=O)Cn1nc-2c(Cc3ccccc-23)cc1=O
Structure:
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