Target
Aldo-keto reductase family 1 member A1
Ligand
BDBM50054328
Substrate
n/a
Meas. Tech.
ChEMBL_31325 (CHEMBL644878)
IC50
92600±n/a nM
Citation
 Costantino, LRastelli, GVescovini, KCignarella, GVianello, PDel Corso, ACappiello, MMura, UBarlocco, D Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors. J Med Chem 39:4396-405 (1996) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member A1
Synonyms:
AK1A1_RAT | Akr1a1 | Aldehyde reductase | Alr
Type:
PROTEIN
Mol. Mass.:
36509.97
Organism:
Rattus norvegicus
Description:
ChEMBL_31321
Residue:
325
Sequence:
MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALSVGYRHIDCASVYGNETEIGEALKESVGAGKAVPREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSITPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY
  
Inhibitor
Name:
BDBM50054328
Synonyms:
4-(3-Oxo-5,6-dihydro-3H-benzo[h]cinnolin-2-yl)-butyric acid | CHEMBL342158
Type:
Small organic molecule
Emp. Form.:
C16H16N2O3
Mol. Mass.:
284.3098
SMILES:
OC(=O)CCCn1nc-2c(CCc3ccccc-23)cc1=O
Structure:
Search PDB for entries with ligand similarity: