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Target
Methylated-DNA--protein-cysteine methyltransferase
Ligand
BDBM50068792
Substrate
n/a
Meas. Tech.
ChEMBL_144712 (CHEMBL751007)
IC50
30±n/a nM
Citation
 McElhinney, RS; Donnelly, DJ; McCormick, JE; Kelly, J; Watson, AJ; Rafferty, JA; Elder, RH; Middleton, MR; Willington, MA; McMurry, TB; Margison, GP Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain. J Med Chem 41:5265-71 (1999) [PubMed]  Article 
Target
Name:
Methylated-DNA--protein-cysteine methyltransferase
Synonyms:
6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN
Type:
PROTEIN
Mol. Mass.:
21651.27
Organism:
Homo sapiens (Human)
Description:
ChEMBL_144711
Residue:
207
Sequence:
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPGLGGSSGLAGAWLKGAGATSGSPPAGRN
  
Inhibitor
Name:
BDBM50068792
Synonyms:
6-(Thiophen-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylamine | CHEMBL151579
Type:
Small organic molecule
Emp. Form.:
C10H11N5OS
Mol. Mass.:
249.292
SMILES:
NC1=Nc2nc[nH]c2C(N1)OCc1cccs1 |t:1|
Structure:
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