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Target
Methylated-DNA--protein-cysteine methyltransferase
Ligand
BDBM5491
Substrate
n/a
Meas. Tech.
ChEMBL_144711 (CHEMBL751006)
IC50
40±n/a nM
Citation
 McElhinney, RS; Donnelly, DJ; McCormick, JE; Kelly, J; Watson, AJ; Rafferty, JA; Elder, RH; Middleton, MR; Willington, MA; McMurry, TB; Margison, GP Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain. J Med Chem 41:5265-71 (1999) [PubMed]  Article 
Target
Name:
Methylated-DNA--protein-cysteine methyltransferase
Synonyms:
6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN
Type:
PROTEIN
Mol. Mass.:
21651.27
Organism:
Homo sapiens (Human)
Description:
ChEMBL_144711
Residue:
207
Sequence:
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPGLGGSSGLAGAWLKGAGATSGSPPAGRN
  
Inhibitor
Name:
BDBM5491
Synonyms:
6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6-Substituted Guanine Deriv. 31
Type:
Small organic molecule
Emp. Form.:
C12H11N5O
Mol. Mass.:
241.2486
SMILES:
Nc1nc(OCc2ccccc2)c2[nH]cnc2n1
Structure:
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