Target
Prostaglandin G/H synthase 2
Ligand
BDBM50339185
Substrate
n/a
Meas. Tech.
ChEMBL_159907 (CHEMBL768956)
IC50
18900±n/a nM
Citation
 Puig, CCrespo, MIGodessart, NFeixas, JIbarzo, JJiménez, JMSoca, LCardelús, IHeredia, AMiralpeix, MPuig, JBeleta, JHuerta, JMLópez, MSegarra, VRyder, HPalacios, JM Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors. J Med Chem 43:214-23 (2000) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
COX2 | Cyclooxygenase | Cyclooxygenase 2 (COX-2) | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2 AA) | Cyclooxygenase-2 (COX-2 AEA) | Cyclooxygenase-2 (COX-2) | PGH synthase 2 | PGH2_HUMAN | PGHS-2 | PHS II | PTGS2 | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Type:
Enzyme
Mol. Mass.:
69003.89
Organism:
Homo sapiens (Human)
Description:
Recombinant Cox-2 provided by Cayman (Cayman Chemical Co.,Ann Arbor, MI).
Residue:
604
Sequence:
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
  
Inhibitor
Name:
BDBM50339185
Synonyms:
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | (S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid | (S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | (S)-naproxen | 2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(6-Methoxy-naphthalen-2-yl)-propionic acid(naproxen) | 2-(6-methoxy-2-naphthyl)propanoic acid | 2-(6-methoxynaphthalen-2-yl)propanoic acid | Aleve | Anaprox | CHEMBL154 | Ec-naprosyn | Equiproxen | Naprelan | Naprosyn | Naproxen | Naproxen2-(6-Methoxy-naphthalen-2-yl)-propionic acid | RS-3540 | S-NAPROXEN | US11459295, Compound S-Naproxen (1) | naproxene
Type:
Small organic molecule
Emp. Form.:
C14H14O3
Mol. Mass.:
230.2592
SMILES:
COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: