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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50102578
Substrate
n/a
Meas. Tech.
ChEMBL_61359 (CHEMBL673261)
IC50
2.8±n/a nM
Citation
 Meltzer, PC; Wang, B; Chen, Z; Blundell, P; Jayaraman, M; Gonzalez, MD; George, C; Madras, BK Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. J Med Chem 44:2619-35 (2001) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50102578
Synonyms:
7-Hydroxy-8-methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL86654
Type:
Small organic molecule
Emp. Form.:
C20H23NO3
Mol. Mass.:
325.4015
SMILES:
COC(=O)C1C2[C@H](O)CC(CC1c1ccc3ccccc3c1)N2C |TLB:23:22:4.11.10:6.8,12:11:22:6.8,THB:7:6:22:4.11.10,2:4:22:6.8|
Structure:
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