Target
Major prion protein
Ligand
BDBM50017696
Substrate
n/a
Meas. Tech.
ChEMBL_158887 (CHEMBL760875)
EC50
8000±n/a nM
Citation
 Vogtherr, MGrimme, SElshorst, BJacobs, DMFiebig, KGriesinger, CZahn, R Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem 46:3563-4 (2003) [PubMed]  Article 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM50017696
Synonyms:
(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine | 10-(2-Dimethylaminopropyl)phenothiazine | 10-[2-(dimethylamino)propyl]phenothiazine | CHEMBL643 | N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine | N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine | PROMETHAZINE | med.21724, Compound 16 | proazamine
Type:
Small organic molecule
Emp. Form.:
C17H20N2S
Mol. Mass.:
284.419
SMILES:
CC(CN1c2ccccc2Sc2ccccc12)N(C)C
Structure:
Search PDB for entries with ligand similarity: