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Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Ligand
BDBM50170665
Substrate
n/a
Meas. Tech.
ChEMBL_303691 (CHEMBL829736)
Ki
441±n/a nM
Citation
 Laggner, C; Schieferer, C; Fiechtner, B; Poles, G; Hoffmann, RD; Glossmann, H; Langer, T; Moebius, FF Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem 48:4754-64 (2005) [PubMed]  Article 
Target
Name:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Synonyms:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase | 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase | Anti-estrogen binding site (AEBS) | Cholestenol Delta-isomerase | D8-D7 sterol isomerase | Delta(8)-Delta(7) sterol isomerase | EBP | EBP_HUMAN | Emopamil-binding protein
Type:
PROTEIN
Mol. Mass.:
26358.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_873432
Residue:
230
Sequence:
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGTWRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVCMETITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELGHPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
  
Inhibitor
Name:
BDBM50170665
Synonyms:
4a,6a,7,10-tetramethyl-(2S,4aR,4bS,6aS,6bR,7S,10S,12aS,13aS,13bR)-2,3,4,4a,4b,5,6,6a,6b,7,7a,8,9,10,11,12a,13,13a,13b,14-icosahydro-1H-naphtho[2',1':4,5]indeno[1,2-b]indolizin-2-ol | CHEMBL363703
Type:
Small organic molecule
Emp. Form.:
C27H43NO
Mol. Mass.:
397.6364
SMILES:
C[C@@H]1C2CC[C@H](C)CN2[C@H]2C[C@H]3[C@@H]4CC=C5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]3(C)[C@@H]12 |t:15|
Structure:
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