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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50173714
Substrate
n/a
Meas. Tech.
ChEMBL_320797 (CHEMBL884752)
Ki
10±n/a nM
Citation
 Mattson, RJ; Catt, JD; Denhart, DJ; Deskus, JA; Ditta, JL; Higgins, MA; Marcin, LR; Sloan, CP; Beno, BR; Gao, Q; Cunningham, MA; Mattson, GK; Molski, TF; Taber, MT; Lodge, NJ Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors. J Med Chem 48:6023-34 (2005) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50173714
Synonyms:
CHEMBL364050 | [(1S,2S)-2-(7-Fluoro-1H-indol-3-yl)-cyclopropylmethyl]-dimethyl-amine
Type:
Small organic molecule
Emp. Form.:
C14H17FN2
Mol. Mass.:
232.2966
SMILES:
CN(C)C[C@H]1C[C@@H]1c1c[nH]c2c(F)cccc12
Structure:
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