Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM107693
Substrate
n/a
Meas. Tech.
ChEMBL_355503 (CHEMBL871193)
IC50
400±n/a nM
Citation
 Walker, MA; Johnson, T; Ma, Z; Banville, J; Remillard, R; Kim, O; Zhang, Y; Staab, A; Wong, H; Torri, A; Samanta, H; Lin, Z; Deminie, C; Terry, B; Krystal, M; Meanwell, N Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore. Bioorg Med Chem Lett 16:2920-4 (2006) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM107693
Synonyms:
(2Z)-4-(5-chloro-1H-indol-3-yl)-2-hydroxy-4-oxobut-2- enoic acid (Compound 19) | CHEMBL108760
Type:
Small organic molecule
Emp. Form.:
C12H8ClNO4
Mol. Mass.:
265.649
SMILES:
OC(=O)C(=O)CC(=O)c1c[nH]c2ccc(Cl)cc12
Structure:
Search PDB for entries with ligand similarity: