Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Ligand
BDBM50024894
Substrate
n/a
Meas. Tech.
ChEMBL_424365 (CHEMBL911296)
IC50
118±n/a nM
Citation
 Bachelier, AMayer, RKlein, CD Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett 16:5605-9 (2006) [PubMed]  Article 
Target
Name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:
EPT | Enoylpyruvate transferase | MURA_ECOLI | MurA (E. coli) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA | murZ
Type:
Protein
Mol. Mass.:
44814.62
Organism:
Escherichia coli K-12 (Enterobacteria)
Description:
E. coli MurA
Residue:
419
Sequence:
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
  
Inhibitor
Name:
BDBM50024894
Synonyms:
(1R, 2S)-1,2-epoxypropyl-phosphonic acid | (2R,3S)-3-methyloxiran-2-ylphosphonate | (2R,3S)-3-methyloxiran-2-ylphosphonic acid | (3-Methyl-oxiranyl)-phosphonic acid(Na salt) | CHEMBL1757 | FOSFOMYCIN | Fosfomycin (compound 1) | Fosfomycin Calcium | Fosfomycin Sodium | Monurol | phosphomycin
Type:
Small organic molecule
Emp. Form.:
C3H7O4P
Mol. Mass.:
138.059
SMILES:
C[C@@H]1O[C@@H]1P(O)(O)=O |r|
Structure:
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