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TargetProtein-arginine N-methyltransferase 1
LigandBDBM50206433
Substrate/Competitorn/a
Meas. Tech.ChEMBL_428527
IC50 519000±n/a nM
Citation Ragno, RSimeoni, SCastellano, SVicidomini, CMai, ACaroli, ATramontano, ABonaccini, CTrojer, PBauer, IBrosch, GSbardella, G Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem50:1241-53 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-arginine N-methyltransferase 1
Name:Protein-arginine N-methyltransferase 1
Synonyms:Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1)
Type:Protein
Mol. Mass.:41506.52
Organism:Homo sapiens (Human)
Description:n/a
Residue:361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50206433
NameBDBM50206433
Synonyms:4-amino-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid | CHEMBL219901
TypeSmall organic molecule
Emp. Form.C20H13NO5
Mol. Mass.347.3209
SMILESNc1ccc(C(O)=O)c(c1)-c1c2ccc(O)cc2oc2cc(=O)ccc12 |(-.92,-24.4,;-2.25,-25.18,;-3.59,-24.42,;-4.92,-25.2,;-4.91,-26.74,;-6.42,-27.04,;-6.9,-28.5,;-7.43,-25.89,;-3.57,-27.48,;-2.24,-26.72,;-3.56,-29.02,;-2.23,-29.78,;-.9,-29,;.44,-29.76,;.46,-31.31,;1.8,-32.07,;-.88,-32.1,;-2.22,-31.33,;-3.55,-32.1,;-4.89,-31.34,;-6.22,-32.12,;-7.55,-31.35,;-8.89,-32.11,;-7.55,-29.8,;-6.21,-29.06,;-4.89,-29.8,)|
Structure
n/a