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Target
RmtA
Ligand
BDBM50206433
Substrate
n/a
Meas. Tech.
ChEMBL_428528 (CHEMBL919885)
IC50
710000±n/a nM
Citation
 Ragno, R; Simeoni, S; Castellano, S; Vicidomini, C; Mai, A; Caroli, A; Tramontano, A; Bonaccini, C; Trojer, P; Bauer, I; Brosch, G; Sbardella, G Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem 50:1241-53 (2007) [PubMed]  Article 
Target
Name:
RmtA
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
39351.26
Organism:
Emericella nidulans
Description:
ChEMBL_475539
Residue:
345
Sequence:
MSEIENSTITSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVIGVDMSSIIEKAREIVAVNGLADKITLLQGKMEEVQLPFPSVDIIISEWMGYFLLYESMLDTVLYAQDRYLVPGGKIFPDKATMYLAGIEDGEYKDDKIGFWDNVYGFDYSPMKEIALTEPLVDTVELKALVTDPCPIITFDLYTVTKEDLAFEVPYSLPVKRSDFVHAVIAWFDIEFGACHKPINFSTGPHAKYTHWKQTVFYLRDVLTVEEEESISGVLSNRPNDKNKRDLDINLTYKLETQDQTRFAEGGCFYRM
  
Inhibitor
Name:
BDBM50206433
Synonyms:
4-amino-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid | CHEMBL219901
Type:
Small organic molecule
Emp. Form.:
C20H13NO5
Mol. Mass.:
347.3209
SMILES:
Nc1ccc(C(O)=O)c(c1)-c1c2ccc(O)cc2oc2cc(=O)ccc12 |(-.92,-24.4,;-2.25,-25.18,;-3.59,-24.42,;-4.92,-25.2,;-4.91,-26.74,;-6.42,-27.04,;-6.9,-28.5,;-7.43,-25.89,;-3.57,-27.48,;-2.24,-26.72,;-3.56,-29.02,;-2.23,-29.78,;-.9,-29,;.44,-29.76,;.46,-31.31,;1.8,-32.07,;-.88,-32.1,;-2.22,-31.33,;-3.55,-32.1,;-4.89,-31.34,;-6.22,-32.12,;-7.55,-31.35,;-8.89,-32.11,;-7.55,-29.8,;-6.21,-29.06,;-4.89,-29.8,)|
Structure:
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