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Target
Acyl-CoA desaturase 1
Ligand
BDBM50371071
Substrate
n/a
Meas. Tech.
ChEMBL_438936 (CHEMBL889279)
IC50
3±n/a nM
Citation
 Liu, G; Lynch, JK; Freeman, J; Liu, B; Xin, Z; Zhao, H; Serby, MD; Kym, PR; Suhar, TS; Smith, HT; Cao, N; Yang, R; Janis, RS; Krauser, JA; Cepa, SP; Beno, DW; Sham, HL; Collins, CA; Surowy, TK; Camp, HS Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors. J Med Chem 50:3086-100 (2007) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50371071
Synonyms:
CHEMBL227205
Type:
Small organic molecule
Emp. Form.:
C17H19BrN4O2
Mol. Mass.:
391.262
SMILES:
CNC(=O)c1ccc(nn1)N1CCC(CC1)Oc1ccccc1Br
Structure:
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