Reaction Details Report a problem with these data
Target
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Ligand
BDBM50214607
Substrate
n/a
Meas. Tech.
ChEMBL_459093 (CHEMBL926261)
IC50
554±n/a nM
Citation
 Bruno, RD; Njar, VC Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Bioorg Med Chem 15:5047-60 (2007) [PubMed]  Article 
Target
Name:
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Synonyms:
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_HUMAN | CYP1ALPHA | CYP27B | CYP27B1 | Cytochrome P450 27B1
Type:
Protein
Mol. Mass.:
56522.50
Organism:
Homo sapiens (Human)
Description:
O15528
Residue:
508
Sequence:
MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR
  
Inhibitor
Name:
BDBM50214607
Synonyms:
CHEMBL541423 | MK-24 | MK-24(S)-S(O)(NH)Ph
Type:
Small organic molecule
Emp. Form.:
C29H39NO3S
Mol. Mass.:
481.69
SMILES:
C[C@H](CC=S(N)(=O)c1ccccc1)C1=CCC2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |t:14|
Structure:
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