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TargetCytochrome P450 27B1
LigandBDBM50214607
Substrate/Competitorn/a
Meas. Tech.ChEMBL_459093
IC50 554±n/a nM
Citation Bruno, RDNjar, VC Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Bioorg Med Chem15:5047-60 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 27B1
Name:25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Synonyms:25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Type:Protein
Mol. Mass.:56522.50
Organism:Homo sapiens (Human)
Description:O15528
Residue:508
Sequence:
MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR
LHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCR
QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP
ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH
WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFRE
ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS
ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA
QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP
EPGAAPVRPKTRTVLVPERSINLQFLDR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50214607
NameBDBM50214607
Synonyms:CHEMBL541423 | MK-24 | MK-24(S)-S(O)(NH)Ph
TypeSmall organic molecule
Emp. Form.C29H39NO3S
Mol. Mass.481.69
SMILESC[C@H](CC=S(N)(=O)c1ccccc1)C1=CCC2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |t:14|
Structure
n/a