Reaction Details Report a problem with these data
Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50227856
Substrate
n/a
Meas. Tech.
ChEMBL_461588 (CHEMBL927611)
Ki
0.15±n/a nM
Citation
Duan, JJ; Chen, L; Lu, Z; Xue, CB; Liu, RQ; Covington, MB; Qian, M; Wasserman, ZR; Vaddi, K; Christ, DD; Trzaskos, JM; Newton, RC; Decicco, CP Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors. Bioorg Med Chem Lett 18:241-6 (2008) [PubMed] Article
More Info.:
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Sus scrofa (pig)
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
Inhibitor
Name:
BDBM50227856
Synonyms:
(3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)benzamido)-tetrahydro-2H-pyran-3-carboxamide | (3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)benzamido)tetrahydro-2H-pyran-3-carboxamide | CHEMBL252893
Type:
Small organic molecule
Emp. Form.:
C24H25N3O5
Mol. Mass.:
435.4724
SMILES:
Cc1cc(COc2ccc(cc2)C(=O)N[C@@H]2CCOC[C@@H]2C(=O)NO)c2ccccc2n1 |r|