Reaction Details Report a problem with these data
Target
Fibroblast growth factor 1
Ligand
BDBM50374504
Substrate
n/a
Meas. Tech.
ChEMBL_469445 (CHEMBL946803)
IC50
240±n/a nM
Citation
 Liu, L; Bytheway, I; Karoli, T; Fairweather, JK; Cochran, S; Li, C; Ferro, V Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharides. Bioorg Med Chem Lett 18:344-9 (2008) [PubMed]  Article 
Target
Name:
Fibroblast growth factor 1
Synonyms:
Acidic fibroblast growth factor | Beta-endothelial cell growth factor | ECGF-beta | FGF1 | FGF1_HUMAN | FGFA | Fibroblast growth factor 1 (FGF-1) | HBGF-1 | Heparin-binding growth factor 1 | aFGF
Type:
Protein
Mol. Mass.:
17461.01
Organism:
Homo sapiens (Human)
Description:
P05230
Residue:
155
Sequence:
MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD
  
Inhibitor
Name:
BDBM50374504
Synonyms:
CHEMBL258321
Type:
Small organic molecule
Emp. Form.:
C26H44N2O20
Mol. Mass.:
704.629
SMILES:
CCCOC(=O)[C@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H](CO)[C@H](O[C@H]2O[C@@H]([C@H](O[C@@H]3OC[C@H](O)[C@@H](O)[C@@H]3N)[C@@H](O)[C@@H]2O)C(O)=O)[C@@H](O)[C@@H]1N
Structure:
Search PDB for entries with ligand similarity: