Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM51395
Substrate
n/a
Meas. Tech.
ChEMBL_479300 (CHEMBL933672)
IC50
7±n/a nM
Citation
 Myers, MC; Shah, PP; Beavers, MP; Napper, AD; Diamond, SL; Smith, AB; Huryn, DM Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. Bioorg Med Chem Lett 18:3646-51 (2008) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM51395
Synonyms:
CHEMBL263634 | N-[(2S)-1-[[[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethoxy]-oxomethyl]hydrazo]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamic acid tert-butyl ester | N-[[(2S)-2-(tert-butoxycarbonylamino)-3-(1H-indol-3-yl)propanoyl]amino]carbamic acid [2-(3,4-dihydro-2H-quinolin-1-yl)-2-keto-ethyl] ester | PC-0686185 | cid_23631927 | tert-butyl N-[(2S)-1-[2-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxidanylidene-ethoxy]carbonylhydrazinyl]-3-(1H-indol-3-yl)-1-oxidanylidene-propan-2-yl]carbamate | tert-butyl N-[(2S)-1-[2-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethoxy]carbonylhydrazinyl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate
Type:
Small organic molecule
Emp. Form.:
C28H33N5O6
Mol. Mass.:
535.5915
SMILES:
CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)OCC(=O)N1CCCc2ccccc12
Structure:
Search PDB for entries with ligand similarity: