Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50262150
Substrate
n/a
Meas. Tech.
ChEMBL_513609 (CHEMBL967913)
Ki
4±n/a nM
Citation
 Mantri, M; de Graaf, O; van Veldhoven, J; Göblyös, A; von Frijtag Drabbe Künzel, JK; Mulder-Krieger, T; Link, R; de Vries, H; Beukers, MW; Brussee, J; Ijzerman, AP 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem 51:4449-55 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50262150
Synonyms:
5-(((R)-1-((2-chloropyridin-4-yl)methyl)pyrrolidin-2-ylamino)methyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine | CHEMBL513009
Type:
Small organic molecule
Emp. Form.:
C19H20ClN9O
Mol. Mass.:
425.875
SMILES:
Nc1nc(CN[C@H]2CCCN2Cc2ccnc(Cl)c2)nc2nc(nn12)-c1ccco1 |r|
Structure:
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