Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50169338
Substrate
n/a
Meas. Tech.
ChEMBL_513609 (CHEMBL967913)
Ki
4.3±n/a nM
Citation
 Mantri, M; de Graaf, O; van Veldhoven, J; Göblyös, A; von Frijtag Drabbe Künzel, JK; Mulder-Krieger, T; Link, R; de Vries, H; Beukers, MW; Brussee, J; Ijzerman, AP 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem 51:4449-55 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50169338
Synonyms:
2-(furan-2-yl)-7-(2-methoxyphenyl)-[1,2,4]triazolo[1,5-f]pyrimidin-5-amine | 2-Furan-2-yl-7-(2-methoxy-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine | CHEMBL177782
Type:
Small organic molecule
Emp. Form.:
C16H13N5O2
Mol. Mass.:
307.3067
SMILES:
COc1ccccc1-c1cc2nc(nn2c(N)n1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: