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Target
Thioredoxin reductase 2, mitochondrial
Ligand
BDBM50274681
Substrate
n/a
Meas. Tech.
ChEMBL_536730 (CHEMBL981835)
IC50
>200000±n/a nM
Citation
 Casini, A; Gabbiani, C; Sorrentino, F; Rigobello, MP; Bindoli, A; Geldbach, TJ; Marrone, A; Re, N; Hartinger, CG; Dyson, PJ; Messori, L Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds. J Med Chem 51:6773-81 (2008) [PubMed]  Article 
Target
Name:
Thioredoxin reductase 2, mitochondrial
Synonyms:
TRXR2_RAT | Trxr2 | Txnrd2
Type:
PROTEIN
Mol. Mass.:
56441.28
Organism:
Rattus norvegicus
Description:
ChEMBL_700049
Residue:
525
Sequence:
MAAIVAALRGSSGRFRPQTRVLTRGTRGAAGAASAAGGQQNFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAQHYGWEVAQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHGTRFLKGCVPSLIRKLPTNQLQVTWEDLASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGVNTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLDPTVTGCG
  
Inhibitor
Name:
BDBM50274681
Synonyms:
CARBOPLATIN | cbdca | cbdca(2-) | cyclobutane-1,1-dicarboxylate | cyclobutane-1,1-dicarboxylate(2-)
Type:
Small organic molecule
Emp. Form.:
C6H6O4
Mol. Mass.:
142.1105
SMILES:
[O-]C(=O)C1(CCC1)C([O-])=O
Structure:
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