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Target
Kappa-type opioid receptor
Ligand
BDBM50278335
Substrate
n/a
Meas. Tech.
ChEMBL_564844 (CHEMBL955071)
Ki
9±n/a nM
Citation
 Wentland, MP; Lou, R; Lu, Q; Bu, Y; Denhardt, C; Jin, J; Ganorkar, R; VanAlstine, MA; Guo, C; Cohen, DJ; Bidlack, JM Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett 19:2289-94 (2009) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50278335
Synonyms:
(1R,9R,10S,13S)-17-(cyclobutylmethyl)-3,10,13-trihydroxy-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,5-triene-4-carboxamide | CHEMBL512150 | US10231963, Table B.19 | US10287250, Compound B.13 | US10736890, Compound TABLE B.19 | US10752592, Compound TABLE B.13 | US11534436, Compound Table B.19 | US9133125, Table B, Compound 13 | US9656961, Example 00136
Type:
Small organic molecule
Emp. Form.:
C22H30N2O4
Mol. Mass.:
386.4846
SMILES:
NC(=O)c1ccc2C[C@H]3N(CC4CCC4)CC[C@@]4(C[C@@H](O)CC[C@@]34O)c2c1O |r|
Structure:
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