Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor A
Ligand
BDBM50303975
Substrate
n/a
Meas. Tech.
ChEMBL_595237 (CHEMBL1043589)
Ki
13.4±n/a nM
Citation
 Mizuno, CS; Chittiboyina, AG; Shah, FH; Patny, A; Kurtz, TW; Pershadsingh, HA; Speth, RC; Karamyan, VT; Carvalho, PB; Avery, MA Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome. J Med Chem 53:1076-85 (2010) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor A
Synonyms:
AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40910.53
Organism:
RAT
Description:
ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:
359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
  
Inhibitor
Name:
BDBM50303975
Synonyms:
3'-(4-(2-(1H-Tetrazol-5-yl)ethyl)benzyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]-imidaz | CHEMBL566614
Type:
Small organic molecule
Emp. Form.:
C29H30N8
Mol. Mass.:
490.6021
SMILES:
CCCc1nc2c(C)cc(cc2n1Cc1ccc(CCc2nnn[nH]2)cc1)-c1nc2ccccc2n1C
Structure:
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