Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Potassium voltage-gated channel subfamily A member 1
Ligand
BDBM50378799
Substrate
n/a
Meas. Tech.
ChEMBL_650722 (CHEMBL1227482)
EC50
46000±n/a nM
Citation
Pan, Y; Weng, J; Kabaleeswaran, V; Li, H; Cao, Y; Bhosle, RC; Zhou, M Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nat Chem Biol 4:708-14 (2008) [PubMed] Article More Info.:
Target
Name:
Potassium voltage-gated channel subfamily A member 1
Synonyms:
KCNA1 | KCNA1_HUMAN | Potassium (voltage dependent) | Potassium voltage-gated channel subfamily A member 1 | Voltage-gated potassium channel | Voltage-gated potassium channel subfamily A member 1/beta-1 | Voltage-gated potassium channel subunit Kv1.1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56451.30
Organism:
Homo sapiens (Human)
Description:
Potassium (voltage dependent) 0 0::Q09470
Residue:
495
Sequence:
MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV
Inhibitor
Name:
BDBM50378799
Synonyms:
CORTISONE
Type:
Small organic molecule
Emp. Form.:
C21H30O5
Mol. Mass.:
362.4599
SMILES:
C[C@]12CC(=O)[C@H]3[C@@H](CCC4=C[C@H](O)CC[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO |t:9|
Structure:
