Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50326574
Substrate
n/a
Meas. Tech.
ChEMBL_661809 (CHEMBL1252125)
IC50
50±n/a nM
Citation
 El Turk, F; Fauvet, B; Ouertatani-Sakouhi, H; Lugari, A; Betzi, S; Roche, P; Morelli, X; Lashuel, HA An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem 18:5425-40 (2010) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50326574
Synonyms:
6-phenylpyridazin-3-yl thiophene-2-carboxylate | CHEMBL1253380
Type:
Small organic molecule
Emp. Form.:
C15H10N2O2S
Mol. Mass.:
282.317
SMILES:
O=C(Oc1ccc(nn1)-c1ccccc1)c1cccs1
Structure:
Search PDB for entries with ligand similarity: