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Target
Beta-1 adrenergic receptor
Ligand
BDBM50378920
Substrate
n/a
Meas. Tech.
ChEMBL_809479 (CHEMBL2015334)
IC50
1.5±n/a nM
Citation
 Radeke, HS; Purohit, A; Harris, TD; Hanson, K; Jones, R; Hu, C; Yalamanchili, P; Hayes, M; Yu, M; Guaraldi, M; Kagan, M; Azure, M; Cdebaca, M; Robinson, S; Casebier, D Synthesis and Cardiac Imaging of (18)F-Ligands Selective for ß1-Adrenoreceptors. ACS Med Chem Lett 2:650-655 (2011) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50378920
Synonyms:
CHEMBL2011219
Type:
Small organic molecule
Emp. Form.:
C22H28FN5O3
Mol. Mass.:
429.4878
SMILES:
CC(CF)Nc1ccc(NC(=O)NCCNC[C@H](O)COc2ccccc2C#N)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: