Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50379551
Substrate
n/a
Meas. Tech.
ChEMBL_811468 (CHEMBL2013769)
IC50
10±n/a nM
Citation
 Oza, VAshwell, SBrassil, PBreed, JEzhuthachan, JDeng, CGrondine, MHorn, CLiu, DLyne, PNewcombe, NPass, MRead, JSu, MToader, DYu, DYu, YZabludoff, S Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors. Bioorg Med Chem Lett 22:2330-7 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50379551
Synonyms:
CHEMBL2012863
Type:
Small organic molecule
Emp. Form.:
C14H10N4O2
Mol. Mass.:
266.2548
SMILES:
Nc1cc2n[nH]c(=O)n2c2cc(ccc12)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: