Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50383004
Substrate
n/a
Meas. Tech.
ChEMBL_818429 (CHEMBL2034749)
IC50
3.1±n/a nM
Citation
 Taliani, S; Pugliesi, I; Barresi, E; Simorini, F; Salerno, S; La Motta, C; Marini, AM; Cosimelli, B; Cosconati, S; Di Maro, S; Marinelli, L; Daniele, S; Trincavelli, ML; Greco, G; Novellino, E; Martini, C; Da Settimo, F 3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists. J Med Chem 55:1490-9 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50383004
Synonyms:
CHEMBL2030707
Type:
Small organic molecule
Emp. Form.:
C21H13ClN4O
Mol. Mass.:
372.807
SMILES:
Clc1ccc2n(-c3ccccc3)c3nnc(-c4ccccc4)c(=O)n3c2c1
Structure:
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