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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50383906
Substrate
n/a
Meas. Tech.
ChEMBL_819515 (CHEMBL2033320)
IC50
1.1±n/a nM
Citation
 Chu, L; Armstrong, HM; Chang, LL; Cheng, AF; Colwell, L; Cui, J; Evans, J; Galka, A; Goulet, MT; Hayes, N; Lo, J; Menke, J; Ok, HO; Ondeyka, DL; Patel, M; Quaker, GM; Sings, H; Witkin, SL; Zhao, A; Ujjainwalla, F Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors. Bioorg Med Chem Lett 22:4133-8 (2012) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50383906
Synonyms:
CHEMBL2031647
Type:
Small organic molecule
Emp. Form.:
C31H27N3O2S
Mol. Mass.:
505.63
SMILES:
Sc1nnc(o1)-c1ccc(OCc2ccc3ccccc3n2)cc1[C@@]1(C[C@H]2CC[C@H]1C2)c1ccccc1 |r,TLB:31:24:28.27:30,THB:23:24:28.27:30|
Structure:
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