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Target
Cytochrome P450 2C8
Ligand
BDBM50384473
Substrate
n/a
Meas. Tech.
ChEMBL_821903 (CHEMBL2039549)
IC50
79±n/a nM
Citation
 Crosignani, S; Jorand-Lebrun, C; Campbell, G; Prêtre, A; Grippi-Vallotton, T; Quattropani, A; Bouscary-Desforges, G; Bombrun, A; Missotten, M; Humbert, Y; Frémaux, C; Pâquet, M; El Harkani, K; Bradshaw, CG; Cleva, C; Abla, N; Daff, H; Schott, O; Pittet, PA; Arrighi, JF; Gaudet, M; Johnson, Z Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids. ACS Med Chem Lett 2:938-942 (2011) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C8
Synonyms:
CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase
Type:
Protein
Mol. Mass.:
55839.23
Organism:
Homo sapiens (Human)
Description:
P10632
Residue:
490
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
  
Inhibitor
Name:
BDBM50384473
Synonyms:
CHEMBL2036222
Type:
Small organic molecule
Emp. Form.:
C20H22FN5O3S
Mol. Mass.:
431.484
SMILES:
CC(C)CC(=O)N(Cc1ccc(cc1)S(C)(=O)=O)c1cc(F)cc(c1)-c1nnn[nH]1
Structure:
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