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Target
Regulator of G-protein signaling 8
Ligand
BDBM50384776
Substrate
n/a
Meas. Tech.
ChEMBL_821036 (CHEMBL2039223)
IC50
7600±n/a nM
Citation
 Turner, EM; Blazer, LL; Neubig, RR; Husbands, SM Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins. ACS Med Chem Lett 3:146-150 (2012) [PubMed]  Article 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM50384776
Synonyms:
CHEMBL2037228
Type:
Small organic molecule
Emp. Form.:
C15H10ClFN2O2S
Mol. Mass.:
336.769
SMILES:
Fc1ccc(Cn2c(=O)sn(-c3ccc(Cl)cc3)c2=O)cc1
Structure:
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