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Target
Isoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 1
Ligand
BDBM50385309
Substrate
n/a
Meas. Tech.
ChEMBL_822725 (CHEMBL2040042)
Ki
0.640000±n/a nM
Citation
 Bell, IM; Stump, CA; Gallicchio, SN; Staas, DD; Zartman, CB; Moore, EL; Sain, N; Urban, M; Bruno, JG; Calamari, A; Kemmerer, AL; Mosser, SD; Fandozzi, C; White, RB; Zrada, MM; Selnick, HG; Graham, SL; Vacca, JP; Kane, SA; Salvatore, CA MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. Bioorg Med Chem Lett 22:3941-5 (2012) [PubMed]  Article 
Target
Name:
Isoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 1
Synonyms:
Amylin receptor AMY1, CALCR/RAMP1 | Calcitonin receptor (1)/Receptor activity-modifying protein 1
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 822725
Components:
This complex has 2 components.
Component 1
Name:
Isoform 1 of Calcitonin receptor (1)
Synonyms:
CALCR | CALCR_HUMAN | CT-R | Calcitonin receptor | Calcitonin receptor (1)
Type:
PROTEIN
Mol. Mass.:
55343.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_42610
Residue:
474
Sequence:
MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA
  
Component 2
Name:
Receptor activity-modifying protein 1
Synonyms:
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN
Type:
PROTEIN
Mol. Mass.:
16992.80
Organism:
Homo sapiens (Human)
Description:
EBI_100673
Residue:
148
Sequence:
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
  
Component 3
Name:
Isoform 1 of Calcitonin receptor (1)
Synonyms:
CALCR | CALCR_HUMAN | CT-R | Calcitonin receptor | Calcitonin receptor (1)
Type:
PROTEIN
Mol. Mass.:
55343.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_42610
Residue:
474
Sequence:
MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA
  
Inhibitor
Name:
BDBM50385309
Synonyms:
CHEMBL2035983
Type:
Small organic molecule
Emp. Form.:
C31H30F2N6O3
Mol. Mass.:
572.6051
SMILES:
C[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1 |r|
Structure:
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