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Target
Polymerase acidic protein
Ligand
BDBM50115581
Substrate
n/a
Meas. Tech.
ChEMBL_823233 (CHEMBL2040651)
Ki
280±n/a nM
Citation
 Baughman, BM; Jake Slavish, P; DuBois, RM; Boyd, VA; White, SW; Webb, TR Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay. ACS Chem Biol 7:526-34 (2012) [PubMed]  Article 
Target
Name:
Polymerase acidic protein
Synonyms:
Hepatitis C virus polyprotein | PA | PA/PB1 | PA_I34A1 | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2
Type:
PROTEIN
Mol. Mass.:
82573.84
Organism:
Hepatitis C virus
Description:
ChEMBL_64976
Residue:
716
Sequence:
MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
  
Inhibitor
Name:
BDBM50115581
Synonyms:
(Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-enoic acid | 2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-enoic acid | CHEMBL108423 | CHEMBL185721 | CHEMBL573638
Type:
Small organic molecule
Emp. Form.:
C16H12O5
Mol. Mass.:
284.2635
SMILES:
OC(=O)C(=O)CC(=O)c1ccc(Oc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: