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Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM50386308
Substrate
n/a
Meas. Tech.
ChEMBL_826599 (CHEMBL2050767)
IC50
118±n/a nM
Citation
 Dounay, AB; Anderson, M; Bechle, BM; Campbell, BM; Claffey, MM; Evdokimov, A; Evrard, E; Fonseca, KR; Gan, X; Ghosh, S; Hayward, MM; Horner, W; Kim, JY; McAllister, LA; Pandit, J; Paradis, V; Parikh, VD; Reese, MR; Rong, S; Salafia, MA; Schuyten, K; Strick, CA; Tuttle, JB; Valentine, J; Wang, H; Zawadzke, LE; Verhoest, PR Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett 3:187-192 (2012) [PubMed]  Article 
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
AADAT_RAT | Aadat | Kat2 | Kynurenine/alpha-aminoadipate aminotransferase
Type:
PROTEIN
Mol. Mass.:
47788.12
Organism:
Rattus norvegicus
Description:
ChEMBL_826599
Residue:
425
Sequence:
MNYSRFLTATSLARKTSPIRATVEIMSRAPKDIISLAPGSPNPKVFPFKSAVFTVENGSTIRFEGEMFQRALQYSSSYGIPELLSWLKQLQIKLHNPPTVNYSPNEGQMDLCITSGCQDGLCKVFEMLINPGDTVLVNEPLYSGALFAMKPLGCNFISVPSDDCGIIPEGLKKVLSQWKPEDSKDPTKRTPKFLYTIPNGNNPTGNSLTGDRKKEIYELARKYDFLIIEDDPYYFLQFTKPWEPTFLSMDVDGRVIRADSLSKVISSGLRVGFITGPKSLIQRIVLHTQISSLHPCTLSQLMISELLYQWGEEGFLAHVDRAIDFYKNQRDFILAAADKWLRGLAEWHVPKAGMFLWIKVNGISDAKKLIEEKAIEREILLVPGNSFFVDNSAPSSFFRASFSQVTPAQMDLVFQRLAQLIKDVS
  
Inhibitor
Name:
BDBM50386308
Synonyms:
CHEMBL2047861
Type:
Small organic molecule
Emp. Form.:
C9H9ClN2O2
Mol. Mass.:
212.633
SMILES:
N[C@H]1Cc2ccc(Cl)cc2N(O)C1=O |r|
Structure:
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