Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM50386292
Substrate
n/a
Meas. Tech.
ChEMBL_826598 (CHEMBL2050766)
IC50
23±n/a nM
Citation
 Dounay, ABAnderson, MBechle, BMCampbell, BMClaffey, MMEvdokimov, AEvrard, EFonseca, KRGan, XGhosh, SHayward, MMHorner, WKim, JYMcAllister, LAPandit, JParadis, VParikh, VDReese, MRRong, SSalafia, MASchuyten, KStrick, CATuttle, JBValentine, JWang, HZawadzke, LEVerhoest, PR Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett 3:187-192 (2012) [PubMed]  Article 
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:
Enzyme
Mol. Mass.:
47353.09
Organism:
Homo sapiens (Human)
Description:
Q8N5Z0
Residue:
425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
  
Inhibitor
Name:
BDBM50386292
Synonyms:
CHEMBL2047851
Type:
Small organic molecule
Emp. Form.:
C9H10N2O2
Mol. Mass.:
178.1879
SMILES:
N[C@H]1Cc2ccccc2N(O)C1=O |r|
Structure:
Search PDB for entries with ligand similarity: