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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50387308
Substrate
n/a
Meas. Tech.
ChEMBL_828048 (CHEMBL2049742)
IC50
20±n/a nM
Citation
 Dakin, LA; Block, MH; Chen, H; Code, E; Dowling, JE; Feng, X; Ferguson, AD; Green, I; Hird, AW; Howard, T; Keeton, EK; Lamb, ML; Lyne, PD; Pollard, H; Read, J; Wu, AJ; Zhang, T; Zheng, X Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett 22:4599-604 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50387308
Synonyms:
CHEMBL2048866
Type:
Small organic molecule
Emp. Form.:
C15H16ClN3O2S
Mol. Mass.:
337.824
SMILES:
N[C@@H]1CCCN(C1)c1c(Cl)cccc1C=C1SC(O)=NC1=O |r,w:14.15,c:20|
Structure:
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