Target
Natural resistance-associated macrophage protein 1
Ligand
BDBM50387740
Substrate
n/a
Meas. Tech.
ChEMBL_830680 (CHEMBL2061615)
IC50
>10000±n/a nM
Citation
 Zhang, ZKodumuru, VSviridov, SLiu, SChafeev, MChowdhury, SChakka, NSun, JGauthier, SJMattice, MRatkay, LGKwan, RThompson, JCutts, ABFu, JKamboj, RGoldberg, YPCadieux, JA Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors. Bioorg Med Chem Lett 22:5108-13 (2012) [PubMed]  Article 
Target
Name:
Natural resistance-associated macrophage protein 1
Synonyms:
LSH | NRAM1_HUMAN | NRAMP | NRAMP 1 | NRAMP1 | SLC11A1
Type:
PROTEIN
Mol. Mass.:
59878.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_830680
Residue:
550
Sequence:
MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG
  
Inhibitor
Name:
BDBM50387740
Synonyms:
CHEMBL2058893
Type:
Small organic molecule
Emp. Form.:
C16H14Br2N4S3
Mol. Mass.:
518.312
SMILES:
NC(=N)SCc1c(Br)ccc2c1sc1c(CSC(N)=N)c(Br)ccc21
Structure:
Search PDB for entries with ligand similarity: