Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50392924
Substrate
n/a
Meas. Tech.
ChEMBL_853422 (CHEMBL2155280)
IC50
0.1±n/a nM
Citation
 Yu, JLiu, HXia, GLiu, LXu, ZChen, QMa, CSun, XXu, JLi, HLi, PShi, YXiong, BLiu, XShen, J Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitors. ACS Med Chem Lett 3:793-798 (2012) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50392924
Synonyms:
CHEMBL2152223
Type:
Small organic molecule
Emp. Form.:
C23H31ClN2O4S
Mol. Mass.:
467.021
SMILES:
Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@]1(C)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:15.17,20.21,wD:15.18,27.30,TLB:19:20:30.26.27:24.23.22,19:20:22:30.27.29,28:27:20.25.24:22,THB:26:25:22:30.27.29,26:27:20.25.24:22,29:27:20:24.23.22,29:23:20:30.26.27,28:27:20:24.23.22,(11.34,-28.78,;11.34,-27.24,;10,-26.47,;8.67,-27.24,;10.01,-24.93,;11.34,-24.16,;12.67,-24.92,;12.68,-26.47,;14.01,-27.24,;14.77,-28.57,;13.24,-28.56,;15.34,-26.47,;15.5,-24.92,;17.01,-24.6,;17.78,-25.94,;16.74,-27.08,;17.83,-28.17,;16.35,-28.57,;15.24,-29.65,;17.43,-29.66,;18.92,-29.26,;20.12,-27.98,;20.11,-26.5,;21.46,-26.02,;20.42,-27.25,;20.42,-28.84,;21.83,-29.4,;22.84,-28.13,;24.38,-28.07,;22.85,-26.6,;21.45,-28.47,)|
Structure:
Search PDB for entries with ligand similarity: