Target
Methylated-DNA--protein-cysteine methyltransferase
Ligand
BDBM50397045
Substrate
n/a
Meas. Tech.
ChEMBL_863278 (CHEMBL2176221)
IC50
9±n/a nM
Citation
 Zhu, RSeow, HABaumann, RPIshiguro, KPenketh, PGShyam, KSartorelli, AC Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase. Bioorg Med Chem Lett 22:6242-7 (2012) [PubMed]  Article 
Target
Name:
Methylated-DNA--protein-cysteine methyltransferase
Synonyms:
6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN
Type:
PROTEIN
Mol. Mass.:
21651.27
Organism:
Homo sapiens (Human)
Description:
ChEMBL_144711
Residue:
207
Sequence:
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPGLGGSSGLAGAWLKGAGATSGSPPAGRN
  
Inhibitor
Name:
BDBM50397045
Synonyms:
CHEMBL485756
Type:
Small organic molecule
Emp. Form.:
C13H14N6O
Mol. Mass.:
270.2899
SMILES:
NCc1cccc(COc2nc(N)nc3nc[nH]c23)c1
Structure:
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