Target
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Ligand
BDBM50397053
Substrate
n/a
Meas. Tech.
ChEMBL_863496 (CHEMBL2174777)
IC50
11±n/a nM
Citation
 Banerjee, APatil, SPawar, MYGullapalli, SGupta, PKGandhi, MNBhateja, DKBajpai, MSangana, RRGudi, GSKhairatkar-Joshi, NGharat, LA Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model. Bioorg Med Chem Lett 22:6286-91 (2012) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Type:
Enzyme
Mol. Mass.:
51842.76
Organism:
Homo sapiens (Human)
Description:
Q9NP56
Residue:
450
Sequence:
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
  
Inhibitor
Name:
BDBM50397053
Synonyms:
CHEMBL2171422
Type:
Small organic molecule
Emp. Form.:
C24H32N6O2
Mol. Mass.:
436.5499
SMILES:
COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCC(N)CC1
Structure:
Search PDB for entries with ligand similarity: