Reaction Details Report a problem with these data
Target
Prostaglandin G/H synthase 1
Ligand
BDBM50097346
Substrate
n/a
Meas. Tech.
ChEMBL_862248 (CHEMBL2172929)
IC50
22300±n/a nM
Citation
Favia, AD; Habrant, D; Scarpelli, R; Migliore, M; Albani, C; Bertozzi, SM; Dionisi, M; Tarozzo, G; Piomelli, D; Cavalli, A; De Vivo, M Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem 55:8807-26 (2012) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68868.60
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
Inhibitor
Name:
BDBM50097346
Synonyms:
(+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid | 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid | 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid(carprofen) | 2-(6-chloro-9H-carbazol-2-yl)propanoic acid | CARPROFEN | CHEMBL1316 | Rimadyl | Ro-20-5720/000
Type:
Small organic molecule
Emp. Form.:
C15H12ClNO2
Mol. Mass.:
273.714
SMILES:
CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21