Target
Proteasome subunit beta type-2
Ligand
BDBM50398608
Substrate
n/a
Meas. Tech.
ChEMBL_874480 (CHEMBL2184803)
IC50
28±n/a nM
Citation
 Kale, AJMoore, BS Molecular mechanisms of acquired proteasome inhibitor resistance. J Med Chem 55:10317-27 (2012) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50398608
Synonyms:
MARIZOMIB
Type:
Small organic molecule
Emp. Form.:
C15H20ClNO4
Mol. Mass.:
313.777
SMILES:
C[C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2CCCl)[C@@H](O)[C@H]1CCCC=C1 |r,c:21|
Structure:
Search PDB for entries with ligand similarity: